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For publications in connection with TRR 374, please state the following: "Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), project number 509149993, TRR 374".

 

 

2025

Ousingsawat J, Talbi K, Gómez-Martín H, Koy A, Fernández-Jaén A, Tekgül H, Serdaro?lu E, Ortigoza-Escobar JD, Schreiber R, Kunzelmann K.
Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1.
BMC Med. 2025 Jan 7;23(1):12. doi: 10.1186/s12916-024-03839-5. PMID: 39773217; PMCID: PMC11707858.
PubMed (external link, opens in a new window)

Schreiber R, Ousingsawat J, Kunzelmann K.
Anoctamin 9 determines Ca2+ signals during activation of T-lymphocytes.
Front Immunol. 2025 Mar 26;16:1562871. doi: 10.3389/fimmu.2025.1562871. PMID: 40207216; PMCID: PMC11979140.
PubMed (external link, opens in a new window)

            

2024

Schueler J, Kuenzel J, Thuesing A, Pion E, Behncke RY, Haegerling R, Fuchs D, Kraus A, Buchholz B, Huang B, Merhof D, Werner JM, Schmidt KM, Hackel C, Aung T, H?rteis S.
Ultra high frequency ultrasound enables real-time visualization of blood supply from chorioallantoic membrane to human autosomal dominant polycystic kidney tissue.
Sci Rep 14, 10063 (2024). doi.org/10.1038/s41598-024-60783-3 (external link, opens in a new window)
PDF (external link, opens in a new window)

Ousingsawat J, Centeio R, Reyne N, McCarron A, Cmielewski P, Schreiber R, diStefano G, R?mermann D, Seidler U, Donnelley M, Kunzelmann K.
Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine.
Sci Rep. 2024 Jan 17;14(1):1464. doi: 10.1038/s41598-024-51397-w. PMID: 38233410; PMCID: PMC10794189.
PubMed (external link, opens in a new window)

Ousingsawat J, Centeio R, Schreiber R, Kunzelmann K.
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract.
Pflugers Arch. 2024 Feb;476(2):211-227. doi: 10.1007/s00424-023-02878-w. Epub 2023 Nov 18. PMID: 37979051; PMCID: PMC10791962.
PubMed (external link, opens in a new window)

Sandersfeld M, Büttner-Herold M, Ferrazzi F, Amann K, Benz K, Daniel C.
Macrophage subpopulations in pediatric patients with lupus nephritis and other inflammatory diseases affecting the kidney.
Arthritis Res Ther. 2024 Feb 8;26(1):46. doi: 10.1186/s13075-024-03281-1. PMID: 38331818; PMCID: PMC10851514.
PubMed (external link, opens in a new window)

Sure F, Einsiedel J, Gmeiner P, Duchstein P, Zahn D, Korbmacher C, Ilyaskin AV.
The small molecule activator S3969 stimulates the epithelial sodium channel (ENaC) by interacting with a specific binding pocket in the channel's β-subunit.
J Biol Chem. 2024 Feb 22:105785. doi: 10.1016/j.jbc.2024.105785. Epub ahead of print. PMID: 38401845.
PubMed (external link, opens in a new window)

Angeloni M, van Doeveren T, Lindner S, Volland P, Schmelmer J, Foersch S, Matek C, Stoehr R, Geppert CI, Heers H, Wach S, Taubert H, Sikic D, Wullich B, van Leenders GJ, Zaburdaev V, Eckstein M, Hartmann A, Boormans JL, Ferrazzi F, Bahlinger V.
A deep-learning workflow to predict upper tract urothelial carcinoma protein-based subtypes from H&E slides supporting the prioritization of patients for molecular testing.
J Pathol Clin Res. 2024 Mar;10(2):e12369. doi: 10.1002/2056-4538.12369. PMID: 38504364; PMCID: PMC10951050.
PubMed (external link, opens in a new window)

Miyauchi H, Geisberger S, Luft FC, Wilck N, Stegbauer J, Wiig H, Dechend R, Jantsch J, Kleinewietfeld M, Kempa S, Müller DN.
Sodium as an Important Regulator of Immunometabolism.
Hypertension. 2024 Mar;81(3):426-435. doi: 10.1161/HYPERTENSIONAHA.123.19489. Epub 2023 Sep 7. PMID: 37675565; PMCID: PMC10863658.
PubMed (external link, opens in a new window)

Skoczynski K, Kraus A, Daniel C, Büttner-Herold M, Amann K, Schiffer M, Hermann K, Herrnberger-Eimer L, Tamm ER, Buchholz B.
The extracellular matrix protein fibronectin promotes metanephric kidney development.
Pflugers Arch. 2024 Apr 2. doi: 10.1007/s00424-024-02954-9. Epub ahead of print. PMID: 38563997.
PubMed (external link, opens in a new window)

K?sters P, Cazorla-Vázquez S, Krüger R, Daniel C, Vonbrunn E, Amann K, Engel FB.
Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
Cells. 2024 May 18;13(10):874. doi: 10.3390/cells13100874. PMID: 38786096; PMCID: PMC11119830.
PubMed (external link, opens in a new window)

Schlieben LD, Carta MG, Moskalev EA, St?hr R, Metzler M, Besend?rfer M, Meidenbauer N, Semrau S, Janka R, Grützmann R, Wiemann S, Hartmann A, Agaimy A, Haller F, Ferrazzi F.
Machine Learning-Supported Diagnosis of Small Blue Round Cell Sarcomas Using Targeted RNA Sequencing.
J Mol Diagn. 2024 May;26(5):387-398. doi: 10.1016/j.jmoldx.2024.02.002. Epub 2024 Feb 21. PMID: 38395409.
PubMed (external link, opens in a new window)

Schreiber R, Ousingsawat J, Kunzelmann K.
The anoctamins: Structure and function.
Cell Calcium. 2024 Jun;120:102885. doi: 10.1016/j.ceca.2024.102885. Epub 2024 Apr 15. PMID: 38642428.
PubMed (external link, opens in a new window)

Kunzelmann K, Ousingsawat J, Schreiber R. VSI:
The anoctamins: Structure and function: "Intracellular" anoctamins.
Cell Calcium. 2024 Jun;120:102888. doi: 10.1016/j.ceca.2024.102888. Epub 2024 Apr 17. PMID: 38657371.
PubMed (external link, opens in a new window)

Ousingsawat J, Talbi K, Gómez-Martín H, Koy A, Fernández-Jaén A, Tekgül H, Serdaro?lu E, Schreiber R, Ortigoza-Escobar JD, Kunzelmann K.
Broadening the clinical spectrum: molecular mechanisms and new phenotypes of ANO3-dystonia.
Brain. 2024 Jun 3;147(6):1982-1995. doi: 10.1093/brain/awad412. PMID: 38079528.
PubMed (external link, opens in a new window)

Kraus A, Skoczynski K, Br?tsch M, Burzlaff N, Leipziger J, Schiffer M, Büttner-Herold M, Buchholz B.
P2Y2R and Cyst Growth in Polycystic Kidney Disease.
J Am Soc Nephrol. 2024 Jun 7. doi: 10.1681/ASN.0000000000000416. Epub ahead of print. PMID: 38848134.
Pubmed (external link, opens in a new window)

Vonbrunn E, Daniel C.
Die Komplementkaskade in der Nierenpathologie [The complement cascade in renal pathology].
Pathologie (Heidelb). 2024 Jul;45(4):246-253. German. doi: 10.1007/s00292-024-01320-x. Epub 2024 Apr 5. PMID: 38578365.
PubMed (external link, opens in a new window)

Büttner-Herold M, Amann K, Velden J.
Nephropathologie infekti?ser Erkrankungen [Nephropathology of infectious disease].
Pathologie (Heidelb). 2024 Jul;45(4):254-260. German. doi: 10.1007/s00292-024-01322-9. Epub 2024 Apr 10. PMID: 38598098.
PubMed (external link, opens in a new window)

Wopperer FJ, Olinger E, Wiesener A, Broeker KAE, Knaup KX, Schaefer JT, Galiano M, Schneider K, Schiffer M; Genomics England Research Consortium; Büttner-Herold M, Reis A, Schmieder R, Pasutto F, Hilgers KF, Poglitsch M, Ziegler C, Shoemaker R, Sayer JA, Wiesener MS.
Progressive Kidney Failure by Angiotensinogen Inactivation in the Germline.
Hypertension. 2024 Sep;81(9):1857-1868. doi: 10.1161/HYPERTENSIONAHA.124.22806. Epub 2024 Jul 15. PMID: 39005223.
PubMed (external link, opens in a new window)

Ousingsawat J, Schreiber R, Kunzelmann K.
Functional Interdependence of Anoctamins May Influence Conclusions from Overexpression Studies.
Int J Mol Sci. 2024 Sep 17;25(18):9998. doi: 10.3390/ijms25189998. PMID: 39337485; PMCID: PMC11432102.
PubMed (external link, opens in a new window)

Sure F, Afonso S, Essigke D, Schmidt P, Kalo MZ, Nesterov V, Ki?ler A, Bertog M, Rinke R, Wittmann S, Broeker KAE, Gramberg T, Artunc F, Korbmacher C, Ilyaskin AV.

Transmembrane Serine Protease 2 and Proteolytic Activation of the Epithelial Sodium Channel in Mouse Kidney.
J Am Soc Nephrol. 2024 Oct 23. doi: 10.1681/ASN.0000000521. Epub ahead of print. PMID: 39441656.
PubMed (external link, opens in a new window)

Herold JM, Wiegrebe S, Nano J, Jung B, Gorski M, Thorand B, Koenig W, Zeller T, Zimmermann ME, Burkhardt R, Banas B, Küchenhoff H, Stark KJ, Peters A, B?ger CA, Heid IM.
Population-based reference values for kidney function and kidney function decline in 25- to 95-year-old Germans without and with diabetes.
Kidney Int. 2024 Oct;106(4):699-711. doi: 10.1016/j.kint.2024.06.024. Epub 2024 Jul 29. PMID: 39084259.
PubMed (external link, opens in a new window)

Jensen M, Heinl ES, Federlein A, Schwartz U, Lund L, Madsen K, Jensen BL, Schweda F.
Identification of natriuretic peptide receptor A-related gene expression signatures in podocytes in vivo reveals baseline control of protective pathways.
Am J Physiol Renal Physiol. 2024 Nov 1;327(5):F806-F821. doi: 10.1152/ajprenal.00394.2023. Epub 2024 Sep 19. PMID: 39298549.
PubMed (external link, opens in a new window)

  

2023

Vonbrunn E, Büttner-Herold M, Amann K, Daniel C.
Complement Inhibition in Kidney Transplantation: Where Are We Now?
BioDrugs. 2023 Jan;37(1):5-19. doi: 10.1007/s40259-022-00567-1. Epub 2022 Dec 13. PMID: 36512315; PMCID: PMC9836999.
PubMed (external link, opens in a new window)

Schanz M, Kimmel M, Alscher MD, Amann K, Daniel C.
TIMP-2 and IGFBP7 in human kidney biopsies in renal disease.
Clin Kidney J. 2023 Jan 16;16(9):1434-1446. doi: 10.1093/ckj/sfad010. PMID: 37664566; PMCID: PMC10468751.
PubMed (external link, opens in a new window)

Kraus A, Lüdke A, Teschemacher B, Skoczynski K, Buchholz B.
In vitro cyst puncture and injury-induced tubule formation using renal epithelial cells.
STAR Protoc. 2023 Jan 19;4(1):101874. doi: 10.1016/j.xpro.2022.101874. Epub ahead of print. PMID: 36856763; PMCID: PMC10037192.
PubMed (external link, opens in a new window)

Schreiber R, Talbi K, Ousingsawat J, Kunzelmann K.
A TMEM16J variant leads to dysregulated cytosolic calcium which may lead to renal disease.
FASEB J. 2023 Jan;37(1):e22683. doi: 10.1096/fj.202200968R. PMID: 36520003.
PubMed (external link, opens in a new window)

C?rte-Real BF, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen MW, Kurniawan H, Wagner A, Yosef N, Weiss SNY, Schmetterer KG, Schr?der A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois LJ, Brenner D, Kempa S, Hafler DA, Stegbauer J, Linker RA, Jantsch J, Müller DN, Kleinewietfeld M.
Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs.
Cell Metab. 2023 Feb 7;35(2):299-315.e8. doi: 10.1016/j.cmet.2023.01.009. PMID: 36754020.
PubMed (external link, opens in a new window)

Dagorn PG, Buchholz B, Kraus A, Batchuluun B, Bange H, Blockken L, Steinberg GR, Moller DE, Hallakou-Bozec S.
A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease.
Kidney Int. 2023 Feb 18:S0085-2538(23)00122-9. doi: 10.1016/j.kint.2023.01.026. Epub ahead of print. PMID: 36804411.
PubMed (external link, opens in a new window)

Donhauser FJ, Zimmermann ME, Steinkirchner AB, Wiegrebe S, Dietl A, Brandl C, Burkhardt R, Gessner A, Schweda F, Bergler T, Sch?ffner E, B?ger CA, Kronenberg F, Luchner A, Stark KJ, Heid IM.
Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study.
J Clin Med. 2023 Mar 7;12(6):2102. doi: 10.3390/jcm12062102. PMID: 36983106; PMCID: PMC10054695.
PubMed (external link, opens in a new window)

Heinl ES, Broeker KA, Lehrmann C, Heydn R, Krieger K, Ortmaier K, Tauber P, Schweda F.
Localization of natriuretic peptide receptors A, B, and C in healthy and diseased mouse kidneys.
Pflugers Arch. 2023 Mar;475(3):343-360. doi: 10.1007/s00424-022-02774-9. Epub 2022 Dec 8. PMID: 36480070; PMCID: PMC9908653.
PubMed (external link, opens in a new window)

Sinha F, Federlein A, Biesold A, Schwarzfischer M, Krieger K, Schweda F, Tauber P.
Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting duct.
Front Pharmacol. 2023 Mar 23;14:1118358. doi: 10.3389/fphar.2023.1118358. PMID: 37033639; PMCID: PMC10076569.
PubMed (external link, opens in a new window)

Grampp S, Krüger R, Lauer V, Uebel S, Knaup KX, Naas J, H?ffken V, Weide T, Schiffer M, Naas S, Sch?del J.
Hypoxia hits APOL1 in the kidney.
Kidney Int. 2023 Apr 23:S0085-2538(23)00266-1. doi: 10.1016/j.kint.2023.03.035. Epub ahead of print. PMID: 37098381.
PubMed (external link, opens in a new window)

Grampp S, Kraus A, Skoczynski K, Schiffer M, Krüger R, Naas S, Sch?del J, Buchholz B.
Hypoxia induces polycystin-1 expression in the renal epithelium.
R. Soc. OpenSci. 2023 10: 220992.
https://doi.org/10.1098/rsos.220992 (external link, opens in a new window)

Centeio R, Cabrita I, Schreiber R, Kunzelmann K.
TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium.
Front Physiol. 2023 May 9;14:1157704. doi: 10.3389/fphys.2023.1157704. PMID: 37234411; PMCID: PMC10206426.
PubMed (external link, opens in a new window)

Herold JM, Nano J, Gorski M, Winkler TW, Stanzick KJ, Zimmermann ME, Brandl C, Peters A, Koenig W, Burkhardt R, Gessner A, Heid IM, Gieger C, Stark KJ.
Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly - comparative results from the KORA and AugUR study.
BMC Genom Data. 2023 May 25;24(1):28. doi: 10.1186/s12863-023-01130-9. PMID: 37231333; PMCID: PMC10210501.
PubMed (external link, opens in a new window)

Naas S, Krüger R, Knaup KX, Naas J, Grampp S, Schiffer M, Wiesener M, Sch?del J.
Hypoxia controls expression of kidney-pathogenic MUC1 variants.
Life Sci Alliance. 2023 Jun 14;6(9):e202302078. doi: 10.26508/lsa.202302078. PMID: 37316299; PMCID: PMC10267510.
PubMed (external link, opens in a new window)

B?hme R, Daniel C, Ferrazzi F, Angeloni M, Ekici AB, Winkler TH, Hilgers KF, Wellmann U, Voll RE, Amann K.
Cardiovascular changes in the NZB/W F1 mouse model of lupus nephritis.
Front Cardiovasc Med. 2023 Jul 24;10:1182193. doi: 10.3389/fcvm.2023.1182193. PMID: 37554366; PMCID: PMC10405627.
PubMed (external link, opens in a new window)

Cazorla-Vázquez S, K?sters P, Bertz S, Pfister F, Daniel C, Dedden M, Zundler S, Jobst-Schwan T, Amann K, Engel FB.
Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney.
Cells. 2023 Aug 2;12(15):1988. doi: 10.3390/cells12151988. PMID: 37566066; PMCID: PMC10417176.
PubMed (external link, opens in a new window)

Kunzelmann K, Ousingsawat J, Kraus A, Park JH, Marquardt T, Schreiber R, Buchholz B.
Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins.
Int J Mol Sci. 2023 Aug 26;24(17):13278. doi: 10.3390/ijms241713278. PMID: 37686084; PMCID: PMC10487509.
PubMed (external link, opens in a new window)

Talbi K, Ousingsawat J, Centeio R, Schreiber R, Kunzelmann K.
KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage dependent Cl- channel and is not expressed in renal proximal tubule.
Pflugers Arch. 2023 Aug;475(8):995-1007. doi: 10.1007/s00424-023-02829-5. Epub 2023 Jul 13. PMID: 37442855; PMCID: PMC10359377.
PubMed (external link, opens in a new window)

Naas S, Schiffer M, Sch?del J.
Hypoxia and renal fibrosis.
Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C999-C1016. doi: 10.1152/ajpcell.00201.2023. Epub 2023 Sep 4. PMID: 37661918.
PubMed (external link, opens in a new window)

Wahida A, Schmaderer C, Büttner-Herold M, Branca C, Donakonda S, Haberfellner F, Torrez C, Schmitz J, Schulze T, Seibt T, ?llinger R, Engleitner T, Haller B, Steiger K, Günthner R, Lorenz G, Yabal M, Bachmann Q, Braunisch MC, Moog P, Matevossian E, A?falg V, Thorban S, Renders L, Sp?th MR, Müller RU, Stippel DL, Weichert W, Slotta-Huspenina J, von Vietinghoff S, Viklicky O, Green DR, Rad R, Amann K, Linkermann A, Br?sen JH, Heemann U, Kemmner S.
High RIPK3 expression is associated with a higher risk of early kidney transplant failure.
iScience. 2023 Sep 17;26(10):107879. doi: 10.1016/j.isci.2023.107879. PMID: 37868627; PMCID: PMC10585402.
PubMed (external link, opens in a new window)

Sinha F, Schweda F, Maier LS, Wagner S.
Impact of Impaired Kidney Function on Arrhythmia-Promoting Cardiac Ion Channel Regulation.
International Journal of Molecular Sciences. 2023; 24(18):14198.
https://doi.org/10.3390/ijms241814198 (external link, opens in a new window)

Stanzick KJ, Stark KJ, Gorski M, Sch?del J, Krüger R, Kronenberg F, Warth R, Heid IM, Winkler TW.
KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies.
BMC Bioinformatics. 2023 Sep 21;24(1):355. doi: 10.1186/s12859-023-05472-0.
Pubmed (external link, opens in a new window)

Meindl K, Issler N, Afonso S, Cebrian-Serrano A, Müller K, Sterner C, Othmen H, Tegtmeier I, Witzgall R, Klootwijk E, Davies B, Kleta R, Warth R.
A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility.
Front Cell Dev Biol. 2023 Oct 12;11:1240558. doi: 10.3389/fcell.2023.1240558.
Pubmed (external link, opens in a new window)

Gaupp C, Schmid B, Tripal P, Edwards A, Daniel C, Zimmermann S, Goppelt-Struebe M, Willam C, Rosen S, Schley G.
Reconfiguration and loss of peritubular capillaries in chronic kidney disease.
Sci Rep. 2023 Nov 11;13(1):19660. doi: 10.1038/s41598-023-46146-4. PMID: 37952029; PMCID: PMC10640592.
PubMed (external link, opens in a new window)

Ousingsawat J, Talbi K, Gómez-Martín H, Koy A, Fernández-Jaén A, Tekgül H, Serdaro?lu E, Schreiber R, Ortigoza-Escobar JD, Kunzelmann K.
Broadening the clinical spectrum: molecular mechanisms and new phenotypes of ANO3-dystonia.
Brain. 2023 Dec 11:awad412. doi: 10.1093/brain/awad412. Epub ahead of print. PMID: 38079528.
PubMed (external link, opens in a new window)

Kunzelmann K, Centeio R, Ousingsawat J, Talbi K, Seidler U, Schreiber R.
SLC26A9 in airways and intestine: secretion or absorption?
Channels (Austin). 2023 Dec;17(1):2186434. doi: 10.1080/19336950.2023.2186434. PMID: 36866602; PMCID: PMC9988340.
PubMed (external link, opens in a new window)

Krampert L, Ossner T, Schr?der A, Schatz V, Jantsch J.
Simultaneous Increases in Intracellular Sodium and Tonicity Boost Antimicrobial Activity of Macrophages.
Cells. 2023 Dec 11;12(24):2816. doi: 10.3390/cells12242816. PMID: 38132136; PMCID: PMC10741518.
PubMed (external link, opens in a new window)

 

2022

Fuchs MAA, Schrankl J, Leupold C, Wagner C, Kurtz A, Broeker K.
Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.
Am J Physiol Renal Physiol. 2022 Jan 17. doi: 10.1152/ajprenal.00414.2021. Epub ahead of print. PMID: 35037469.
PubMed (external link, opens in a new window)

W?rner S, Bohnert BN, W?rn M, Xiao M, Janessa A, Birkenfeld AL, Amann K, Daniel C, Artunc F.
Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice.
Acta Pharmacol Sin. 2022 Jan;43(1):111-120. doi: 10.1038/s41401-021-00628-1. Epub 2021 Mar 23. PMID: 33758357; PMCID: PMC8724274.
PubMed (external link, opens in a new window)

Niederreiter J, Eck C, Ries T, Hartmann A, M?rkl B, Büttner-Herold M, Amann K, Daniel C.
Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19. Front Immunol. 2022 Feb 2;13:835156. doi: 10.3389/fimmu.2022.835156. PMID: 35237273; PMCID: PMC8884149.
PubMed (external link, opens in a new window)

Arzt M, Drzymalski MA, Ripfel S, Meindl S, Biedermann A, Durczok M, Keller K, Mustroph J, Katz S, Tafelmeier M, Lebek S, Fl?rchinger B, Camboni D, Wittmann S, Backs J, Schmid C, Maier LS, Wagner S.
Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing.
Antioxidants (Basel). 2022 Feb 8;11(2):331. doi: 10.3390/antiox11020331. PMID: 35204213; PMCID: PMC8868143.
PubMed (external link, opens in a new window)

Issler N, Afonso S, Weissman I, Jordan K, Cebrian-Serrano A, Meindl K, Dahlke E, Tziridis K, Yan G, Robles-López JM, Tabernero L, Patel V, Kesselheim A, Klootwijk ED, Stanescu HC, Dumitriu S, Iancu D, Tekman M, Mozere M, Jaureguiberry G, Outtandy P, Russell C, Forst AL, Sterner C, Heinl ES, Othmen H, Tegtmeier I, Reichold M, Schiessl IM, Limm K, Oefner P, Witzgall R, Fu L, Theilig F, Schilling A, Shuster Biton E, Kalfon L, Fedida A, Arnon-Sheleg E, Ben Izhak O, Magen D, Anikster Y, Schulze H, Ziegler C, Lowe M, Davies B, B?ckenhauer D, Kleta R, Falik Zaccai TC, Warth R.
A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness.
J Am Soc Nephrol. 2022 Feb 11: epub ahead of print. doi: 10.1681/ASN.2021101312.
Pubmed (external link, opens in a new window)
Editorial (external link, opens in a new window)

Wester M, Pec J, Lebek S, Fisser C, Debl K, Hamer O, Poschenrieder F, Buchner S, Maier LS, Arzt M, Wagner S.
Sleep-Disordered Breathing Is Associated With Reduced Left Atrial Strain Measured by Cardiac Magnetic Resonance Imaging in Patients After Acute Myocardial Infarction.
Front Med (Lausanne). 2022 Feb 16;9:759361. doi: 10.3389/fmed.2022.759361. PMID: 35252229; PMCID: PMC8888827.
PubMed (external link, opens in a new window)

Broeker KAE, Fuchs MAA, Schrankl J, Lehrmann C, Schley G, Todorov VT, Hugo C, Wagner C, Kurtz A.
Prolyl-4-hydroxylases 2 and 3 control erythropoietin production in renin-expressing cells of mouse kidneys.
J Physiol. 2022 Feb;600(3):671-694. doi: 10.1113/JP282615. Epub 2021 Dec 27. PMID: 34863041.
PubMed (external link, opens in a new window)

Baumgartner A, Reichelt-Wurm S, Gronwald W, Samol C, Schr?der JA, Fellner C, Holler K, Steege A, Putz FJ, Oefner PJ, Banas B, Banas MC.
Assessment of Physiological Rat Kidney Ageing-Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation.
Metabolites. 2022 Feb 8;12(2):162. doi: 10.3390/metabo12020162. PMID: 35208236; PMCID: PMC8875225.
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Protze J, Naas S, Krüger R, St?hr C, Kraus A, Grampp S, Wiesener M, Schiffer M, Hartmann A, Wullich B, Sch?del J.
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Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C.
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Clin Chem. 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334.
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Lo J, Forst AL, Warth R, Zdebik AA.
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Front Physiol. 2022 Mar 15;13:852674. doi: 10.3389/fphys.2022.852674.
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Vonbrunn E, Angeloni M, Büttner-Herold M, Müller-Deile J, Heller K, Bleich E, S?llner S, Amann K, Ferrazzi F, Daniel C.
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Front Med (Lausanne). 2022 Mar 30;9:793744. doi: 10.3389/fmed.2022.793744. PMID: 35433772; PMCID: PMC9005644.
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Baier MJ, Wagner S, Hupf J, Evert K, Evert M, Sossalla S, Jungbauer C, Maier LS, Neef S, Mustroph J.
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Sure F, Bertog M, Afonso S, Diakov A, Rinke R, Madej MG, Wittmann S, Gramberg T, Korbmacher C, Ilyaskin AV.
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J Biol Chem. 2022 Apr 30:102004. doi: 10.1016/j.jbc.2022.102004 . Epub ahead of print. PMID: 35504352 .
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Scholz JK, Kraus A, Lüder D, Skoczynski K, Schiffer M, Grampp S, Sch?del J, Buchholz B.
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iScience. 2022 May 5;25(6):104359. doi: 10.1016/j.isci.2022.104359. PMID: 35620436; PMCID: PMC9127160.
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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Commun Biol. 2022 Jun 13;5(1):580. doi: 10.1038/s42003-022-03448-z. PMID: 35697829; PMCID: PMC9192715.
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Heinz V, Güler G, Leone V, Madej MG, Maksimov S, G?rtner RM, Rudi O, Hamdi F, Kastritis PL, M?ntele W, Kr?mer R, Forrest LR, Perez C, Ziegler C.
Osmotic stress response in BetP: How lipids and K+ team up to overcome downregulation.
bioRxiv 2022.06.02.493408; doi: https://doi.org/10.1101/2022.06.02.493408 (external link, opens in a new window)

Bichlmayer EM, Mahl L, Hesse L, Pion E, Haller V, Moehwald A, Hackl C, Werner JM, Schlitt HJ, Schwarz S, Kainz P, Brochhausen C, Groeger C, Steger F, K?lbl O, Daniel C, Amann K, Kraus A, Buchholz B, Aung T, Haerteis S.
A 3D In Vivo Model for Studying Human Renal Cystic Tissue and Mouse Kidney Slices. Cells. 2022 Jul 22;11(15):2269. doi: 10.3390/cells11152269. PMID: 35892566; PMCID: PMC9330914.
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Moulin S, Thomas A, Wagner S, Arzt M, Dubouchaud H, Lamarche F, Bouyon S, Vial G, Godin-Ribuot D, Pépin JL, Arnaud C, Belaidi E.
Intermittent Hypoxia-Induced Cardiomyocyte Death Is Mediated by HIF-1 Dependent MAM Disruption.
Antioxidants (Basel). 2022 Jul 27;11(8):1462. doi: 10.3390/antiox11081462. PMID: 36009181; PMCID: PMC9405320.
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Diakov A, Nesterov V, Dahlmann A, Korbmacher C.
Two adjacent phosphorylation sites in the C-terminus of the channel's α-subunit have opposing effects on epithelial sodium channel (ENaC) activity.
Pflugers Arch. 2022 Jul;474(7):681-697. doi: 10.1007/s00424-022-02693-9. Epub 2022 May 8. Erratum in: Pflugers Arch. 2022 Jun 9;: PMID: 35525869; PMCID: PMC9192390.
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Wopperer FJ, Knaup KX, Stanzick KJ, Schneider K, Jobst-Schwan T, Ekici AB, Uebe S, Wenzel A, Schliep S, Schürfeld C, Seitz R, Bernhardt W, G?del M, Wiesener A, Popp B, Stark KJ, Gr?ne HJ, Friedrich B, Wei? M, Basic-Jukic N, Schiffer M, Schr?ppel B, Huettel B, Beck BB; Genomics England Research Consortium, Sayer JA, Ziegler C, Büttner-Herold M, Amann K, Heid IM, Reis A, Pasutto F, Wiesener MS.
Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases.
Kidney Int. 2022 Aug;102(2):405-420. doi: 10.1016/j.kint.2022.04.031. Epub 2022 May 26. PMID: 35643372.
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Skoczynski K, Kraus A, Büttner-Herold M, Amann K, Schiffer M, Hermann K, Herrnberger L, Tamm ER, Buchholz B.
The extracellular matrix protein fibronectin modulates metanephric kidney development.
bioRxiv 2022.07.01.497442; doi: doi.org/10.1101/2022.07.01.497442 (external link, opens in a new window)
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Hermann K, Seibold S, Skoczynski K, Buchholz B, Tamm ER, Herrnberger-Eimer L.
Fibronectin deficiency in newborn mice leads to cyst formation in the kidney.
bioRxiv 2022.07.18.500556; doi: doi.org/10.1101/2022.07.18.500556 (external link, opens in a new window)
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Hegner P, Drzymalski M, Biedermann A, Memmel B, Durczok M, Wester M, Floerchinger B, Provaznik Z, Schmid C, Zausig Y, Maier LS, Wagner S.
SAR296968, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Ca2+ Handling and Contractile Function in Human Atrial Cardiomyocytes.
Biomedicines. 2022 Aug 9;10(8):1932. doi: 10.3390/biomedicines10081932. PMID: 36009478; PMCID: PMC9406204.
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Lebek S, Hegner P, Hultsch R, Rohde J, Rupprecht L, Schmid C, Sossalla S, Maier LS, Arzt M, Wagner S.
Nav1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing.
Am J Respir Crit Care Med. 2022 Aug 9. doi: 10.1164/rccm.202205-0981LE. Epub ahead of print. PMID: 35944144.
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Olinger E, Schaeffer C, Kidd K, Elhassan EAE, Cheng Y, Dufour I, Schiano G, Mabillard H, Pasqualetto E, Hofmann P, Fuster DG, Kistler AD, Wilson IJ, Kmoch S, Raymond L, Robert T; Genomics England Research Consortium, Eckardt KU, Bleyer AJ Sr, K?ttgen A, Conlon PJ, Wiesener M, Sayer JA, Rampoldi L, Devuyst O.
An intermediate-effect size variant in UMOD confers risk for chronic kidney disease.
Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2114734119. doi: 10.1073/pnas.2114734119. Epub 2022 Aug 10. PMID: 35947615; PMCID: PMC9388113.
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Pearce D, Manis AD, Nesterov V, Korbmacher C.
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Pflugers Arch. 2022 Aug;474(8):869-884. doi: 10.1007/s00424-022-02732-5. Epub 2022 Jul 27. PMID: 35895103; PMCID: PMC9338908.
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Gorski M, Rasheed H, Teumer A, Thomas LF, Graham SE, Sveinbjornsson G, Winkler TW, Günther F, Stark KJ, Chai JF, Tayo BO, Wuttke M, Li Y, Tin A, Ahluwalia TS, ?rnl?v J, ?svold BO, Bakker SJL, Banas B, Bansal N, Biggs ML, Biino G, B?hnke M, Boerwinkle E, Bottinger EP, Brenner H, Brumpton B, Carroll RJ, Chaker L, Chalmers J, Chee ML, Chee ML, Cheng CY, Chu AY, Ciullo M, Cocca M, Cook JP, Coresh J, Cusi D, de Borst MH, Degenhardt F, Eckardt KU, Endlich K, Evans MK, Feitosa MF, Franke A, Freitag-Wolf S, Fuchsberger C, Gampawar P, Gansevoort RT, Ghanbari M, Ghasemi S, Giedraitis V, Gieger C, Gudbjartsson DF, Hallan S, Hamet P, Hishida A, Ho K, Hofer E, Holleczek B, Holm H, Hoppmann A, Horn K, Hutri-K?h?nen N, Hveem K, Hwang SJ, Ikram MA, Josyula NS, Jung B, K?h?nen M, Karabegovi? I, Khor CC, Koenig W, Kramer H, Kr?mer BK, Kühnel B, Kuusisto J, Laakso M, Lange LA, Lehtim?ki T, Li M, Lieb W; Lifelines Cohort Study, Lind L, Lindgren CM, Loos RJF, Lukas MA, Lyytik?inen LP, Mahajan A, Matias-Garcia PR, Meisinger C, Meitinger T, Melander O, Milaneschi Y, Mishra PP, Mononen N, Morris AP, Mychaleckyj JC, Nadkarni GN, Naito M, Nakatochi M, Nalls MA, Nauck M, Nikus K, Ning B, Nolte IM, Nutile T, O'Donoghue ML, O'Connell J, Olafsson I, Orho-Melander M, Parsa A, Pendergrass SA, Penninx BWJH, Pirastu M, Preuss MH, Psaty BM, Raffield LM, Raitakari OT, Rheinberger M, Rice KM, Rizzi F, Rosenkranz AR, Rossing P, Rotter JI, Ruggiero D, Ryan KA, Sabanayagam C, Salvi E, Schmidt H, Schmidt R, Scholz M, Sch?ttker B, Schulz CA, Sedaghat S, Shaffer CM, Sieber KB, Sim X, Sims M, Snieder H, Stanzick KJ, Thorsteinsdottir U, Stocker H, Strauch K, Stringham HM, Sulem P, Szymczak S, Taylor KD, Thio CHL, Tremblay J, Vaccargiu S, van der Harst P, van der Most PJ, Verweij N, V?lker U, Wakai K, Waldenberger M, Wallentin L, Wallner S, Wang J, Waterworth DM, White HD, Willer CJ, Wong TY, Woodward M, Yang Q, Yerges-Armstrong LM, Zimmermann M, Zonderman AB, Bergler T, Stefansson K, B?ger CA, Pattaro C, K?ttgen A, Kronenberg F, Heid IM.
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
Kidney Int. 2022 Sep;102(3):624-639. doi: 10.1016/j.kint.2022.05.021. Epub 2022 Jun 16. PMID: 35716955.
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Popp B, Ekici AB, Knaup KX, Schneider K, Uebe S, Park J, Bafna V, Meiselbach H, Eckardt KU, Schiffer M, Reis A, Kraus C, Wiesener M.
Prevalence of hereditary tubulointerstitial kidney diseases in the German Chronic Kidney Disease study.
Eur J Hum Genet. 2022 Sep 13. doi: 10.1038/s41431-022-01177-9. Epub ahead of print. PMID: 36100708.
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Schreiber R, Cabrita I, Kunzelmann K.
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f.
Gastro Hep Advances 2022; Vol 1, Issue 6:1088-1098, ISSN 2772-5723, doi.org/10.1016/j.gastha.2022.08.002
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Fuchs MAA, Schrankl J, Wagner C, Daniel C, Kurtz A, Broeker KA.
Localization and characterization of Proenkephalin-A as a potential biomarker for kidney disease in murine and human kidneys.
Biomarkers. 2022 Nov 10:1-15. doi: 10.1080/1354750X.2022.2146196. Epub ahead of print. PMID: 36354355.
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Daniel C, Enghard P, Ratnatunga N, Wijetunge S, Wazil AWM, Zwiener C, Barth JAC, Chandrajith R, Klewer M, Eckhardt KU, Amann K, Freund P, Premarathne S, Pushpakumara WDRN, Nanayakkara N.
Early Ultrastructural Changes in Biopsies From Patients With Symptomatic CKD of Uncertain Etiology.
Kidney Int Rep. 2022 Dec 31;8(3):642-657. doi: 10.1016/j.ekir.2022.12.022. PMID: 36938087; PMCID: PMC10014386.
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