Publications

Selected Publications (1-30).

For all publications please go to PubMed

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1.?????????? Cabrita I, Kraus A, Scholz JK, Skoczynski K, Schreiber R, Kunzelmann K, Buchholz B. Cyst growth in adpkd is prevented by pharmacological and genetic inhibition of tmem16a in vivo. Nature communications 2020;11(1):4320.

2.?????????? Neubert P, Homann A, Wendelborn D, B?r AL, Krampert L, Trum M, Schr?der A, Ebner S, Weichselbaum A, Schatz V, et al. Ncx1 represents an ionic na+ sensing mechanism in macrophages. PLoS biology 2020;18(6):e3000722.

3.?????????? Park JH, Ousingsawat J, Cabrita I, Bettels RE, Gro?e-Onnebrink J, Schmalstieg C, Biskup S, Reunert J, Rust S, Schreiber R, et al. Tmem16a deficiency: A potentially fatal neonatal disease resulting from impaired chloride currents. J Med Genet 2020.

4.?????????? Cabrita I, Benedetto R, Wanitchakool P, Lerias J, Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K. Tmem16a mediated mucus production in human airway epithelial cells. American journal of respiratory cell and molecular biology 2020.

5.?????????? Berg P, Svendsen SL, Sorensen MV, Larsen CK, Andersen JF, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, et al. Impaired renal hco(3) (-) excretion in cystic fibrosis. J Am Soc Nephrol 2020.

6.?????????? Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K. Lipid peroxidation drives renal cyst growth in vitro through activation of tmem16a J Am Soc Nephrol 2019;30:228-242.

7.?????????? Cabrita I, Benedetto R, Schreiber R, Kunzelmann K. Niclosamide repurposed for the treatment of inflammatory airway disease. JCI insight 2019;8:128414.

8.?????????? Benedetto R, Ousingsawat J, Cabrita I, Pinto M, Lerias J, Wanitchakool P, Schreiber R, Kunzelmann K. Plasma membrane localized tmem16 proteins are indispensable for expression of cftr. J Mol Med 2019;97:711-722.

9.?????????? Benedetto R, Cabrita I, Schreiber R, Kunzelmann K. Tmem16a is indispensable for basal mucus secretion in airways and intestine. FASEB J 2019;33:4502-4512.

10.???????? Schreiber R, Ousingsawat J, Wanitchakool P, Sirianant L, Benedetto R, Reiss K, Kunzelmann K. Regulation of tmem16a/ano1 and tmem16f/ano6 ion currents and phospholipid scrambling by ca2+ and plasma membrane lipid J Physiology (London) 2018;596:217-229.

11.???????? Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K. Contribution of tmem16f to pyroptotic cell death. Cell Death Dis 2018;9(3):300.

12.???????? Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin BV, Schenk LK, Pavenstadt H, Schreiber R, Kunzelmann K. Differential effects of anoctamins on intracellular calcium signals. Faseb j 2017;31:2123-2134.

13.???????? Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K. Epithelial chloride transport by cftr requires tmem16a. Scientific Reports 2017;7:12397.

14.???????? Sommer A, Kordowski F, Buch J, Maretzky T, Evers A, Andra J, Dusterhoft S, Michalek M, Lorenzen I, Somasundaram P, et al. Phosphatidylserine exposure is required for adam17 sheddase function. Nature communications 2016;7:11523.

15.???????? Ousingsawat J, Wanitchakool P, Kmit A, Romao AM, Jantarajit W, Schreiber S, Kunzelmann K. Anoctamin 6 mediates effects essential for innate immunity downstream of p2x7-receptors in macrophages. Nat Commun 2015;6:6245-.

16.???????? Faria D, Schlatter E, Witzgall R, Grahammer F, Bandulik S, Schweda F, Bierer S, Rock JR, Heitzmann D, Kunzelmann K, et al. The calcium activated chloride channel anoctamin 1 contributes to the regulation of renal function. Kindey Int 2014;85:1369-1381.

17.???????? Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K. Anoctamin 1 induces calcium-activated chloride secretion and tissue proliferation in polycystic kidney disease. Kidney Int 2014;85:1058-1067.

18.???????? Almaca J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP, Santos M, Heriche JK, et al. High-content sirna screen reveals global enac regulators and potential cystic fibrosis therapy targets. Cell 2013;154:1390-1400.

19.???????? Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, et al. Tmem16a, induces mapk and contributes directly to tum