Publications
2025
Helmbrecht V, Reichelt R, Grohmann D, Orsi WD. Simulated early Earth geochemistry fuels a hydrogen-dependent primordial metabolism.
Nat Ecol Evol. 2025 May;9(5):769-778. doi: 10.1038/s41559-025-02676-w. Epub 2025 Apr 30.
Grohmann D, Grünberger F. Single-molecule sequencing of RNA.
American Chemical Society. 2025 April 24; DOI: 10.1021/acsinfocus.7e9002
2024
Hanelt TN, Treiber N, Treiber T, Lehmann G, Eichner N, Rothmeier T, Schmid G, Reichelt R, Zambelli F, Pavesi G, Grohmann D, Meister G. Endo-bind-n-seq: identifying RNA motifs of RNA binding proteins isolated from endogenous sources.
Life Sci Alliance. 2024 Dec 2;8(2):e202402782. doi: 10.26508/lsa.202402782
Tarau D, Grünberger F, Pilsl M, Reichelt R, Hei? F, K?nig S, Urlaub H, Hausner W, Engel C, Grohmann D. Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment.
Nucleic Acids Research, gkae282, https://doi.org/10.1093/nar/gkae282
2023
Vornholt T, Joncev Z,? Sabatino V,? Panke S,? Ward T.R,? Sparr C,? Jeschek M. An artificial metalloenzyme for atroposelective metathesis. ChemCatChem e202301113. doi:10.1002/cctc.202301113.
Grünberger F, Schmid G, El Ahmad Z, Fenk M, Vogl K, Reichelt R, Hausner W,
Urlaub H, Lenz C, Grohmann D. Uncovering the temporal dynamics and regulatory
networks of thermal stress response in a hyperthermophile using transcriptomics
and proteomics. mBio. 2023 Oct 16:e0217423. doi: 10.1128/mbio.02174-23
Kramm K, Schr?der T, Vera AM, Grabenhorst L, Tinnefeld P, Grohmann D. DNA Origami-Based Single-Molecule Force Spectroscopy and Applications. Methods Mol Biol. 2024;2694:479-507. doi: 10.1007/978-1-0716-3377-9_23
Reichelt R, Rothmeier T, Grünberger F, Willkomm S, Bruckmann A, Hausner W, Grohmann D. The archaeal Lsm protein from Pyrococcus furiosus binds co- transcriptionally to poly(U)-rich target RNAs. Biol Chem. 2023 Sep 15.
doi: 10.1515/hsz-2023-0215
Baes R, Grünberger F, Pyr Dit Ruys S, Couturier M, De Keulenaer S, Skevin S, Van Nieuwerburgh F, Vertommen D, Grohmann D, Ferreira-Cerca S, Peeters E. Transcriptional and translational dynamics underlying heat shock response in the thermophilic crenarchaeon Sulfolobus acidocaldarius. mBio. 2023 Aug 29:e0359322.
doi: 10.1128/mbio.03593-22
Agam G, Gebhardt C, Popara M, M?chtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Mu?oz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schr?der T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T. Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins. Nat Methods. 2023 Apr;20(4):523-535.
doi: 10.1038/s41592-023-01807-0
Seeholzer T, Tarau D, Hollendonner L, Auer A, Rachel R, Grohmann D, Giessibl FJ, Weymouth AJ. A Next-Generation qPlus-Sensor-Based AFM Setup: Resolving Archaeal S-Layer Protein Structures in Air and Liquid. J Phys Chem B. 2023 Aug 10;127(31):6949-6957. doi: 10.1021/acs.jpcb.3c02875
Grünberger F, Jüttner M, Knüppel R, Ferreira-Cerca S*, Grohmann D.* Nanopore-based RNA sequencing deciphers the formation, processing, and modification steps of rRNA intermediates in archaea. RNA. 2023 Aug;29(8):1255-1273. doi:10.1261/rna.079636.123
Dengler L, Meier J, Klingl A, Ni?l L, Bellack A, Grohmann D, Rachel R, Huber H. A novel interdomain consortium from a Costa Rican oil well composed of Methanobacterium?cahuitense sp. nov. and Desulfomicrobium?aggregans sp. nov. Arch Microbiol. 2023 Apr 13;205(5):189. doi: 10.1007/s00203-023-03533-9.
S. H?llerer, M. Jeschek. Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript. Nucleic Acids Research gkad040,