This file was created by the TYPO3 extension publications --- Timezone: CEST Creation date: 2025-09-06 Creation time: 22:59:27 --- Number of references 4 Background While the histological growth pattern (HGP) of liver metastases is frequently evaluated, the same attention is often absent for brain metastases despite evidence suggesting its prognostic significance. This oversight may stem from the lack of a standardized method for assessing the HGP at the macro-metastasis / brain parenchyma interface (MMPIbrain). MetInfilt is the first prospective, imaging-guided trial aimed at standardizing the collection and analysis of the HGP at the MMPIbrain. Methods We recruited fifty patients. The MMPIbrain was identified using preoperative contrast-enhanced T1-weighted MRI. Intraoperative confocal microscopy (CONVIVO) visualized the MMPIbrain, while a YELLOW 560 nm filter in the surgical microscope facilitated precise tissue sampling. Samples from the MMPIbrain and the core of the metastasis were collected for postoperative histological confirmation. Results The protocol achieved successful tissue acquisition from the MMPIbrain in 93.2 % of patients, meeting the study's primary endpoint. Preoperative MRI patterns strongly correlated with infiltrative HGPs, and CONVIVO accurately visualized the MMPIbrain intraoperatively. Exploratory analyses suggest that infiltrative HGPs might negatively impact patient prognosis and represent a potential risk of meningeal metastasis. Conclusions Our neurosurgical protocol allows the successful and precise acquisition of tissue from the MMPIbrain through presurgical imaging, intraoperative microscopy, and fluorescence-assisted sampling. The evaluation of the HGP in our limited patient cohort highlights its potential clinical significance and supports the urgent necessity to investigate it further for the benefit of patients with brain metastases. article 2025 7 24 10.1016/j.tranon.2025.102480 Translational Oncology 60 Elsevier 102480 https://epub.uni-regensburg.de/id/eprint/77463 Martin A. Proescholdt Tommaso Araceli Karl-Michael Schebesch Christian Doenitz Christina Wendl Katja Evert Ekaterina Noeva Julius Hoehne Markus J. Riemenschneider Daniela Hirsch Nils Ole Schmidt Daniela Sparrer Florian Lüke Daniel Heudobler Tobias Pukrop Raquel Blazquez This dissertation explores corporate social responsibility (CSR) and unethical corporate behavior (corporate social irresponsibility, CSI) in a financial context. The four research papers in this dissertation examine the relationship of CSR and CSI with financial performance in a portfolio context and analyze political, cultural, social, and firm-specific factors and their relationship with corporate scandals. This Dissertation also examines how efficient capital markets price corporate scandals and analyzes the relationship between CSR and CSI with corporate payout. thesis_rgbg 2023 6 16 https://epub.uni-regensburg.de/id/eprint/54349 Christian Sparrer article 2022 1879-1751,0167-2681 Journal of Economic Behavior and Organization 202 Elsevier 762-784 https://epub.uni-regensburg.de/id/eprint/52805 Gregor Dorfleitner Christian Kreuzer Christian Sparrer Based on an extensive international dataset containing Thomson Reuters environmental, social and corporate governance (ESG) rating, as well as Thomson Reuters newest controversies and combined score of an average of 2500 companies in the years 2002–2018, this article contributes to the existing discourse of the relationship between corporate social performance and corporate financial performance (CFP) by examining the Fama and French (J Financ Econ 116(1):1–22, 2015) five-factor risk-adjusted performance of positive screened best and worst portfolios, based on a 10% cutoff, respectively, for equally, value- and rank-weighted strategies in the European, US and global market. Furthermore, the controversies score allows us to examine the mid-to-long-term effects of scandals on the CFP without having to rely on the event study methodology. Even though a value-weighted strategy does not show any significant abnormal returns, we examined a significant outperformance for equally weighted worst ESG portfolios and best controversies strategies. These results strongly indicate that this is, on the one hand, driven by low-rated smaller companies (“small sinners”) and clean-coated firms with regard to controversies (“silent saints”) on the other hand. The findings hold for several robustness checks such as adjusting the cutoff rates or splitting the dataset across time. article 2020 1470-8272,1479-179X 10.1057/s41260-020-00178-x Journal of Asset Management 21 Springer 393-412 https://epub.uni-regensburg.de/id/eprint/43486 Gregor Dorfleitner Christian Kreuzer Christian Sparrer