Research

Biochemistry II

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In the focus of our research are enzymes, which are elaborate proteins that catalyse cellular reactions with high specificity and efficiency.?

We are using rational design and directed evolution to

• engineer the stability and catalytic activity of enzymes,
• experimentally reconstruct the natural evolution of enzymes,
• assign functions to uncharacterised enzymes,
• characterize allosteric interactions within multi-enzyme complexes
• and light-regulate enzymatic activity.

To this end, we apply a broad range of experimental and computational methods.

Our work is part of the following research clusters: